Bakersfield to Lone Pine (via Kern Valley)
We can really recommend the drive along Road 178 from Bakersfield to Ridgecrest (not so much the town of Ridgecrest) - the drive is truly stunning! After leaving the flats around Bakersfield you're approaching a steep and narrow canyon, where the road is winding along the cliff side, with sharp rocks jutting out dangerously on your right hand side (hint: with a large RV take the drive westward, then you'll have the river to your right). We camped at a lovely State Forest camp site before Lake Isabella.
The drive around the lake is an interesting detour, but not a "must". Further to the east the road climbs to a plateau which looks very much like the landscape in Joshua Tree National Park - so if you don't have time to visit this park you can get a good impression here of what it might look like.
Death Valley and Red Rock Canyon
Another place well worth visiting, and less than 20 miles west of Las Vegas along Road 159: Red Rock Canyon National Conservation Area - stunning desert landscape, the red rock formations giving it its name, and one of the best basic campgrounds we have seen so far (although: no shade!!).